Adrenergic receptor



The adrenergic receptors are metabolic G protein-coupled receptors. They are the targets of catecholamines. The binding of an agonist to them causes a sympathetic response. The α-2 adrenergic receptor (A2AR) inhibits insulin or glucagons release. The β-1 adrenergic receptor (B1AR) increases cardiac output and secretion of rennin and ghrelin. The β-2 adrenergic receptor (B2AR) triggers many relaxation reactions. The images at the left and at the right correspond to one representative Adrenergic receptor, i.e. the crystal structure of human β-2 adrenergic Receptor (2rh1). See also Beta-2 Adrenergic Receptor.

3D Structures of Adrenergic receptor
Update June 2011

α-2 adrenergic receptor
3kj6, 2r4r, 2r4s – hA2AR + FAB heavy+light chains

1ho9, 1hod – hA2AR peptide (mutant) – NMR

1hof, 1hll - hA2AR peptide – NMR

β-1 adrenergic receptor
2y01 – tB1AR fragment (mutant) – turkey

1dep – tB1AR peptide - NMR

2y00, 2y02, 2y03, 2y04, 2vt4 - tB1AR fragment (mutant) + agonist

2ycw, 2ycx, 2ycz - tB1AR fragment (mutant) + antagonist

β-2 adrenergic receptor
See also Beta-2 Adrenergic Receptor

3pds - hB2AR/T4 lysozyme - human

3p0g – hB2AR/T4 lysozyme + cameloid antibody fragment

2rh1 - hB2AR/T4 lysozyme (mutant)

3d4s - hB2AR/T4 lysozyme (mutant) + cholesterol

3ny8, 3ny9, 3nya – hB2AR + agonist